Active ingredient:

Ceftazidime (as ceftazidime pentahydrate) – 1 g

International Nonproprietary Name – Ceftazidime

ZACEF is bactericidal cephalosporin antibiotic, which mechanism of action is associated with inhibiting of synthesis of bacterial cell walls. It is highly active against broad spectrum of gram-positive and gram-negative bacteria, including strains resistant to gentamycin and other aminoglycosides.  It is highly resistant to most β-lactamase produced gram-positive and gram-negative microorganisms. ZACEF demonstrates high activity in vitro and acts within narrow range of MIC (minimal inhibitory concentration) against most pathogens.

INDICATIONS

Zacef is intended to treat mono- and mixed infections caused by susceptible microorganisms:

·         severe infections: sepsis, bacteremia, peritonitis, meningitis; infections in patients with  some immunodeficiency; in patients of intensive care department, for example, those with infected burns;

·         respiratory infections including pulmonary infections in mucoviscidosis patients;

·         infections  of ENT-organs;

·         infections  of urinary tracts;

·         skin and soft tissue infections;

·         infections  of gastrointestinal tract, biliary tracts and abdominal cavity;

·         bone and articulation infections;

·         infections associated with hemo- and peritoneal dialyses and continuous ambulatory peritoneal dialysis.

Prophylaxis: infections associated with prostate gland surgery (transurethral resection).

ZACEF is prescribed intramuscularly and intravenously.